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KMID : 0614720070500060556
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Journal of Korean Medical Association
2007 Volume.50 No. 6 p.556 ~ p.560
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ANewOptionforAdvancedGastricCancer
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Zang Dae-Young
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Abstract
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Although gastric cancer is the most common cancer and the second leading cause of cancer deaths in Korea, the gnosis for advanced gastric cancer remains poor, and there is no established standard front-line chemotherapy for advanced age. However, many clinical trials have been developed to improve the response rate and survival in patients with advanced gastric cancer. Novel oral fluoropyrimidines, capecitabine and S-1, are substituting inconvenient 5-FU continuous fusions. These oral fluoropyrimidines combined with docetaxel (1-hour infusion) lead to improve anticancer efficacy and venience. Capecitabine and docetaxel combination regimens showed response rates 39~60% with edian survival 9.5~12 months, and major adverse reactions were hand-foot syndrome and neutropenia. Also, S-1 and docetaxel combination regimens showed response rates 46~56% with median survival 14~14.9 months, and major adverse reaction was neutropenia.The combination of docetaxel and novel oral fluoropyrimidine is highly active and well tolerated in atients with advanced gastric cancer. Large randomized clinical trials are warranted to confirm the efficacy of those regimens. so, we are looking rward to having the results from studies of new chemotherapeutic agents and modalities.
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KEYWORD
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AdvancedGastricCancer, Docetaxel, OralFluoropyrimidine
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